Objective: The aim of this study was to investigate the relationship between self-actualization (SA), life satisfaction (LS), and need for cognition (NC), and to study the effects of gender and class on these factors. Method: 512 students recruited from special middle schools for talented students in Shiraz. Students completed the questionnaires in their regular classes. Scales used in current study were the Ahvaz Self Actualization Inventory (ASAI), Multidimensional Students Life Satisfaction Scale (MSLSS), and Need for Cognition Scale (NCS). Results: Pearson correlation analysis manifested that there exists significant relationships between SA, LS, and NC. Furthermore, MANOVA analysis revealed that the effect of class on self actualization and life satisfaction was significant. Also the effect of sex and the interaction effect of class and sex were not significant. Conclusion: This study helps to get a better understanding on self-actualization and need for cognition among students of special middle schools for talented students.