Objective: This article investigates the relationship between handwriting and kinesthesia in mentally retarded students. Method: 126 students with mental retardation (53 girls and 73 boys) aging 9 to 19 years old from two special schools in Shahr-e Rey participated in this survey. A handwriting checklist researcher-made along with the kinesthesia test of Benbow were administered. Result: Correlation coefficient showed that there is a significant relationship between handwriting scores with kinesthesia scores (r = 0.305, p<0.001). Also, there is a negative relationship between kinesthesia and handwriting speed (r = -0.202, p<0.024). There was no significant relationship between kinesthesia with pencil grip, pressure on pencil and pressure on paper. Conclusion: This study provides evidence that use of kinesthetic exercises can be useful in developing handwriting legibility and speed in students with mental retardation.