Objective: The aim of the current study was to investigate the relation between spiritual intelligence and mental health in mothers of children with and without intellectual disabilities (ID). Method: In this correlational research, the population consisted of students with mild ID, and mothers of regular school students in Gorgan. Eighty mothers were sampled through a multistage sampling procedure and then Brief Symptom Inventory (BSI) and Spiritual Intelligence Self- Report Inventory (SISRI-42) were administered. Results: Results of the study showed a significant relation between spiritual intelligence and mental health in mothers of students with mild ID and mothers of regular school children. In addition, results indicated that mental health of mothers can be predicted by their spiritual intelligence. Conclusion: Based on the acquired findings from this research, it is possible to train the components of spiritual intelligence as a method to improve mental health in these mothers.