Objective: This study examines whether epilepsy can affect self-esteem, perfectionism and academic performance of students with epilepsy in compare with normal students. Method: The sample included 22 students with epilepsy aged from 12 to 18 years and also 22 normal students were matched with them in school and high school students in the Ahvaz. The Rosenberg self-esteem scale and Ahvaz Perfectionism Scale in both groups were administered individually. The subjects' average scores of the previous year in their academic performance were considered. For analyzing the data, MANOVA was used. Results: The results showed there are significant differences between the students with epilepsy and non-epileptic students in the self-esteem scores and in academic performance (p<0/01). So students with epilepsy in terms of self-esteem and academic performance were poorer. Conclusion: This study shows adolescents with epilepsy have poorer self-esteem and academic performance in comparison to adolescents without epilepsy.