Objective: The aim of this study was to determine the effectiveness of the family-oriented sensorymotor empowerment program on the reading ability of students with Down syndrome. Method: The research design was a quasi-experimental pre-testpost-test with a control group. The statistical population included all students with Down syndrome in Kashan City in the academic year of 2021-2022. The research sample consisted of 30 students in the age range of 8-12 years, who were selected by available sampling method and assigned to experimental and control groups (each consisted of 15 children). The data collection tool was Kormi Nouri and Moradi's reading and dyslexia test (2004). Covariance test was used to analyze the data. Results: The results showed a substantial difference between the experimental and control groups in terms of reading ability (p<0.01). Conclusion: Based on the research results, we suggest the family-oriented sensory-motor empowerment program as a suitable intervention to improve the reading ability of students with Down syndrome.