Objective: Mindful-based interventions have been the focus of attention among the followers of the third wave of cognitive-behavioral interventions in recent years. A variety of interventional techniques such as acceptance, emotional control, cognitive restructuring, confrontation, and attention to the present moment are increasingly incorporated into the interventional framework directed to help the parents and caregivers of those with intellectual disability. Method: The present study was a meta-analysis investigating the effectiveness of mindfulness-based interventions in alleviating the psychological problems experienced by the parents and caregivers of people with intellectual disability. Seven studies were selected with a total of 211 participants: 181 mothers and 22 fathers of people with intellectual disability. Results: The results indicated the effectiveness of mindfulness-based interventions in reducing stress and improving psychological factors such as mental health, life expectancy, parenting skills, and interaction strategies in the target population.