Objective: This study investigates the impact of life skills training program (developed by World Health Organization, 1993) on mental health and socio-emotional aspects in women with physical-motor disabilities. Method: 16 women with physical-motor disabilities were randomly selected and assigned into experimental and control groups. First, GHQ was administered for the both groups as the pre-test. Then, ten weekly training sessions were administered for the experimental group, and in each session one of the basic skills propounded in life skills was trained. At the end of sessions, GHQ was again administered for the both groups as post-test. Results: The covariance analysis showed that life skills training could enhance the mental health (p < 0.01), and could decrease anxiety and social maladjustment, but not depression. Conclusion: This study has helped to get a better understanding for delivering mental health service for the targeted groups.