Objective: The purpose of this study was to examine the impact of early family-centered psychological and educational interventions on adaptive behaviors in Children with Down Syndrome (DS). Method: Utilizing an experimental pretest-posttest control group design, parents of 36 children with DS were selected in Isfahan. Vineland Adaptive Behavior Scale was used to assess adaptive behavior. Result: Covariance analysis revealed a significant difference between the adaptive behavior of children with DS in the two groups. Conclusion: This research stresses that early psychological and educational family-centered interventions have a positive effect on adaptive behaviors in children with DS.