Objective: This research investigates a causal model for explanation of depression in mothers having children with and without intellectual disabilities ID. Method: The sample group consisted of 75 mothers of children with ID, and 75 mothers of normal children from Uromia schools. The groups were matched on their education, social class, age, gender and student level of education. In the designed model perceived emotional intelligence (measured by TMMS), negative thought control abilities (measured by TCQ) exogenous variable, psychological well-being moderator variable (measured by Ryff psychological well-being scale) and depression (evaluated by Beck depression inventory) indigenous variable were considered. The scales assessed psychometric characteristics through exploratory and confirmatory factor analysis. The initial model modified according to results and tested through structural equations model. Results: The findings indicated good fitness for normal children mothers and model variables are able to explain psychological well-being. Conversely, the model is not suitable for the mothers of children with ID. Furthermore, thought control strategies are able to explain depression in both groups. Conclusion: Clinical implications are discussed.