Objective: The purpose of this study was to investigate the effectiveness of cognitive behavioral group training of life skills on adjustment in people with vision loss in Isfahan. Method: The 21 participants of this experimental study were all university students with vision loss. Bell Adjustment Inventory was used to measure the adjustment of students. Result:  After gathering and analyzing of the data with covariance statistical analysis, the following results were revealed a significant difference. Conclusion: This study shows that life skills cognitive behavioral group training could have a positive effect on adjustment in university students with vision loss.